14-3-3 proteins: a family of versatile molecular regulators
نویسندگان
چکیده
منابع مشابه
14-3-3 proteins: a family of versatile molecular regulators.
The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene...
متن کاملThe arabidopsis 14-3-3 family of signaling regulators.
The 14-3-3 family of proteins has received much attention in the literature during the last 10 years. The current interest is not surprising given the number of diverse organisms in which 14-3-3s have been identified and the important role that they play in signal transduction. Moore and Perez initially catalogued the 14-3-3 proteins in 1967 during an extensive study in which bovine brain prote...
متن کامل14-3-3 Proteins are Regulators of Autophagy
14-3-3 proteins are implicated in the regulation of proteins involved in a variety of signaling pathways. 14-3-3-dependent protein regulation occurs through phosphorylation-dependent binding that results, in many cases, in the release of survival signals in cells. Autophagy is a cell digestion process that contributes to overcoming nutrient deprivation and is initiated under stress conditions. ...
متن کامل14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins.
A family of proteins known as 14-3-3 is currently receiving increased attention by investigators studying a broad range of biological systems, including plants and invertebrates. The outstanding feature of this family is the extraordinarily high sequence conservation observed. Current thinking indicates that these proteins may function as regulators in signal transduction/phosphorylation mechan...
متن کاملThe 14-3-3 proteins
So what’s so interesting about them? In 1996 14-3-3 was found to bind to a variety of oncoproteins including Raf-1, polyoma middle T, and Bcr-Abl. Since then the 14-3-3 proteins have been shown to bind to a wide variety of proteins involved in signal transduction, cell cycle and apoptosis. These proteins include Cdc25, NFAT, Bad, Cbl, A20, PI 3-kinase, IRS-1, MEKK, p130Cas, glucocorticoid recep...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physiological Research
سال: 2008
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.931598